Ahman Green gets the records and most of the yards but humbly shares the credit.
When he was winded, the Packers lost little with backups Najeh Davenport and Tony Fisher, who combined for 87 yards in 17 carries.
"I consider it a 1-2-3 punch," Coach Mike Sherman said.
Although Green is the NFC's leading rusher, Davenport (6.3) and Fisher (5.7) have higher averages than Green's 5.2 yards per carry.
"Najeh's 250 pounds and just as fast as I am," Green said. "I told both of them in training camp that they'd be a big part of this. I keep telling them that they're just as important to the offense as I am."
The Packers gained 243 yards in 48 carries for a 5.1-yard average. That's their heaviest reliance on the run since Oct. 4, 1981, when they ran 49 times against the New York Giants.
"No wonder I'm sore," center Mike Flanagan said. "Hey, when it's clicking, it's clicking. It didn't matter who we put back there, those guys were all running hard and making the right cuts."
Green set franchise records with his fourth straight 100-yard game and his eighth of the season. He also surpassed John Brockington as the second-leading rusher in team history, trailing only Jim Taylor.
The Packers (6-5) beat the 49ers (5-6) for the 10th time in 11 tries behind Brett Favre, who threw two touchdown passes, including a 66-yarder to Javon Walker. That gave Favre at least 20 touchdowns for the 10th straight season, tying Dan Marino's NFL record.
The 49ers' fourth-ranked run defense had allowed just one 100-yard game this season, to Arizona's Marcel Shipp.
Favre threw three interceptions in a misty rain despite having practiced with wet footballs during the week.
The 49ers failed to capitalize on the first two before converting his third pickoff into points. Terrell Owens caught a 24-yard pass from Tim Rattay in broken coverage on fourth down to pull San Francisco to 17-10 late in the third quarter.
Ryan Longwell's 37-yard field goal with 7:44 left gave Green Bay a 20-10 lead.