A batch of disappointing company earnings news helped put investors in a selling mood Tuesday, pulling U.S. stocks sharply lower.
Healthcare companies led the broad market slide, which more than wiped out gains from the day before. Materials, utilities and technology stocks were among the big decliners. Energy stocks also closed lower as crude oil prices declined.
Several companies, including Alcoa, reported quarterly results that fell short of Wall Street's expectations.
The Dow Jones industrial average fell 200.38 points, or 1.1%, to 18,128.66. Earlier, the average was down as much as 267 points. The Standard & Poor's 500 index lost 26.93 points, or 1.2%, to 2,136.73. The Nasdaq composite index slid 81.89 points, or 1.5%, to 5,246.79.
Indexes headed lower from the start of trading Tuesday and never got out of the red. Traders hammered shares in Alcoa and genetics research company Illumina after the companies reported results that fell short of financial analysts' forecasts.
Alcoa, which is due to split into two companies Nov. 1, slid $3.60, or 11.4%, to $27.91. Illumina sank $45.86, or 24.8%, to $138.99.
Fastenal also delivered quarterly results that failed to impress investors. The maker of industrial and construction fasteners fell $2.16, or 5.1%, to $39.96.
Traders also sold shares in St. Jude Medical after the medical device maker warned that the lithium battery in some of its implanted heart devices may run out of energy prematurely. The stock lost $2.87, or 3.5%, to $78.41. Shares in Abbott Laboratories, which in April agreed to buy St. Jude for $25 billion, also fell. Abbott slid $2.34, or 5.4%, to $41.16.
Some companies benefited from others' bad news.
Apple was got a slight boost after rival Samsung announced that it was discontinuing its Galaxy Note 7 phone permanently because of overheating handsets. The Galaxy Note 7 competed with Apple's iPhone. Apple gained 25 cents to $116.30.
Crude oil prices fell a day after spiking to their highest level in a year. Benchmark U.S. crude oil lost 56 cents, or 1.1%, to close at $50.79 a barrel in New York. Brent, the international standard, slid 73 cents, or 1.4%, to close at $52.41 a barrel in London.
In other energy trading, wholesale gasoline fell a penny to $1.48 a gallon. Heating oil slipped 2 cents to $1.59 a gallon. Natural gas shed 4 cents to $3.24 per 1,000 cubic feet.
The major stock indexes in Europe also closed lower.
Germany's DAX fell 0.4%, while France's CAC 40 slid 0.6%. Britain's FTSE 100 slipped 0.4%. Markets in Asia were mixed. Japan's benchmark Nikkei 225 rose 1%, while Australia's S&P/ASX 200 added 0.1%. South Korea's Kospi lost 1.2%. Hong Kong's Hang Seng dropped 1.4%.
In metals trading, gold fell $4.50 to $1,255.90 an ounce. Silver slid 15 cents to $17.51 an ounce. Copper dropped a penny to $2.19 a pound.
Bond prices fell. The yield on the 10-year Treasury rose to 1.77% from 1.72% on Friday. Bond markets were closed Monday.
In currency markets, the dollar strengthened to 103.41 yen from 103.68 on Monday. The euro fell to $1.1053 from $1.1139.
5:00 p.m.: This article was updated with more recent data after the close of markets.
7:50 a.m.: This article was updated throughout with more recent prices and additional information.