Johnson & Johnson begins huge study of single-shot coronavirus vaccine
Johnson & Johnson is beginning a huge final study to try to prove if a single-dose COVID-19 vaccine can protect recipients from the coronavirus.
The study starting Wednesday will be one of the world’s largest coronavirus vaccine studies so far, testing the shot in 60,000 volunteers in the U.S., South Africa, Argentina, Brazil, Chile, Colombia, Mexico and Peru.
A handful of other vaccines in the U.S. — including shots made by Moderna and Pfizer — and others in other countries are already in final-stage testing. Hopes are high that answers about at least one candidate being tested in the U.S. could come by year’s end, maybe sooner.
U.S. health officials insist that the race for a vaccine isn’t cutting corners.
“We want to do everything we can without sacrificing safety or efficacy — we’re not going to do that — to make sure that we end up with vaccines that are going to save lives,” Dr. Francis Collins, director of the National Institutes of Health, told reporters.
But many vaccine specialists question whether the Food and Drug Administration will stick to that goal under intense pressure from the Trump administration. President Trump has consistently presented a faster timeline for a new vaccine than experts say is adequate to fully test the candidates.
The first wave of coronavirus vaccines might be like a flu shot, experts say, curbing symptoms in some patients but not protecting them from COVID-19.
Meanwhile, testing of another experimental vaccine, made by AstraZeneca, remains on hold in the U.S. as officials examine a safety question, even though studies have resumed in other countries.
Earlier this week, Vice President Mike Pence urged state governors to “do your part to build public confidence that it will be a safe and effective vaccine.”
And Dr. Anthony Fauci, the top U.S. infectious disease expert, added in the call to governors that he has confidence in “a tried-and-true process” with built-in checks and balances, including an independent board evaluating the progress of each vaccine trial, as well as “the integrity of the FDA.”
A recording of the call was provided to the Associated Press.
A pause in a major vaccine trial shows why Trump can’t rush science.
Senators were scheduled to question FDA Commissioner Stephen Hahn, Fauci and other administration officials later Wednesday about the pandemic response.
Even if the FDA were to allow emergency use of a vaccine by year’s end, supplies would be limited and given first to vulnerable groups such as healthcare workers. Most Americans aren’t likely to receive a vaccine until sometime next year.
The Centers for Disease Control and Prevention wants states to get ready now to roll out vaccinations, which will present enormous logistical challenges. The CDC is set Wednesday to announce distribution of $200 million in congressionally approved funds to help begin setting up operations.
Johnson & Johnson’s vaccine candidate is made with slightly different technology from other vaccines in late-stage testing. It is modeled on an Ebola vaccine the company created.
Unlike the other three vaccines that started late-stage testing in the U.S., it requires only one shot, not two. Despite a later start to testing than some of its competitors, Dr. Paul Stoffels, the company’s chief scientific officer, told reporters that the study was large enough to yield answers possibly by early next year.