Jordan Clarkson will miss at least a week of action after suffering a moderate left calf strain.
Clarkson said the calf tightened up on him in the second quarter of the Lakers' second preseason game on Thursday night during the Lakers' 120-105 loss to the Golden State Warriors at Staples Center.
The rookie guard left the game with 36 seconds left in the first half and didn't return. He finished with seven points and three rebounds in almost 13 minutes.
Clarkson (46th overall pick), acquired on a draft-night trade with the Washington Warriors, was the Lakers' leading scorer on Monday in the team's preseason opener, scoring 14 points (on 3-13 shooting) in a 98-95 win over the Denver Nuggets.
Coach Byron Scott has used Clarkson as Kobe Bryant's primary backup at shooting guard.
The team is also without Nick Young for about eight weeks as he recovers from thumb surgery. Ryan Kelly (hamstring) and Xavier Henry (back) hope to practice soon with the team.
Clarkson's absence should give Wayne Ellington, who is currently on a non-guaranteed contract, more time on the court.
The Lakers play the Warriors again on Sunday in Ontario at Citizens Business Bank Arena.