Carlik Jones made a spinning layup and a free throw with 24.5 seconds left, sending Radford to a 62-59 upset of No. 17 Texas on Friday night.
Devin Hutchison made one of two free throws with 11 seconds left before Texas' Jase Febres missed a 3-pointer to tie and Radford rebounded to end the game.
It was the second big road win for Radford (6-1), which beat Notre Dame earlier this season.
Texas dropped a crushing loss. The Longhorns came in with their highest ranking in four seasons under coach Shaka Smart, but shot just 35 percent at home.
Ed Polite Jr. scored 11 to lead Radford. Jericho Sims scored 16 for the Longhorns (5-2).
No. 9 Michigan State 78, at Rutgers 69: Cassius Winston scored 22 points and Nick Ward had 20 points to lead Michigan State past Rutgers in the Big Ten opener.
After a back-and-forth first half, where Rutgers led much of the first 10 minutes, Winston hit a 3-pointer to give Michigan State (5-2) the 39-37 lead over Rutgers (5-2) at the break.
Rutgers would open the second half with a 3-pointer by Peter Kiss from the top of the arc to retake the lead, but a quick 6-0 run from Michigan State caused Rutgers coach Steve Pikiell to call timeout down 45-40 with 17:54 to go. The deficit would eventually balloon to 13.
Eugene Omoruyi led Rutgers with 16 points and 11 rebounds.
No. 22 Wisconsin 72, at No. 14 Iowa 66: D'Mitrik Trice scored 20 points, including a crucial 3 with 20 seconds left, and Wisconsin held off Iowa in the Big Ten opener for both teams.
Ethan Happ had 13 points, seven boards and five assists for the Badgers (7-1), who handed the resurgent Hawkeyes their first loss of the season.
With the Badgers up 65-63, Trice — who led the nation at 60 percent on 3s entering play — hit his 3-pointer.
Jordan Bohannon answered with a quick 3 for Iowa (6-1), but Wisconsin was able to seal it at the line.
No. 21 Buffalo 96, Milwaukee 77: Jeremy Harris scored 21 points, Nick Perkins added 20 with nine rebounds, and Buffalo beat Milwaukee in the Basketball Hall of Fame Belfast Classic.
CJ Massinburg added 16 points as the Bulls improved to 6-0 for the first time since the 1930-31 season.
Buffalo advanced to Saturday's championship game in the Goliath bracket where they will meet San Francisco (7-0), a 76-58 winner over Stephen F. Austin.
No. 25 Mississippi State 65, at Dayton 58: Nick Weatherspoon hit a pair of 3-pointers in the closing minutes, and Mississippi State trailed most of the game before rallying to a victory over Dayton.
The Bulldogs (6-1) salvaged their first true road game by hitting late 3s after missing 15 of their first 19 tries from behind the arc. Weatherspoon's 3-pointer from the corner with 27 seconds left put the Bulldogs up 61-55. He finished with 14 points.
Quinndary Weatherspoon led Mississippi State with 21 points and 12 rebounds, two shy of his career high.
Ryan Mikesell scored 15 points for Dayton (4-3).
Abilene Christian at Pepperdine 5 p.m.
Cal Lutheran at Cal State Fullerton 6 p.m.
Long Beach State at San Diego 7 p.m.
Mississippi Valley State at Cal Baptist 7 p.m.
Utah State at UC Irvine 7 p.m.
Sacramento State at Cal State Northridge 7 p.m.