Steven Dean Gordon, 45, and Franc Cano, 28, were indicted on special-circumstances murder in the commission of a kidnapping and rape, the Orange County district attorney's office said.
Each is charged with four felony counts of special circumstances murder during the commission of rape, kidnapping, lying in wait and multiple murders. They are also each charged with four felony counts of forcible rape.
If convicted, they face a minimum sentence of life in state prison without the possibility of parole and are eligible for the death penalty.
The grand jury heard from 16 witnesses over three days and returned an indictment on the fourth day of the hearing. The indictments allow prosecutors to bypass a preliminary hearing and proceed straight to trial.
The men are expected to be arraigned Friday morning at Central Justice Center in Santa Ana.