Colts quarterback Andrew Luck will miss his first NFL game on Sunday against Jacksonville with a right shoulder injury.
He had started the first 57 games of his career, including the playoffs.
Luck was limited in practice all week and the move allows him to get a few more days of rest before the Colts visit Houston on Thursday.
Also, the Panthers are without star linebacker Luke Kuechly for the third straight week. He's out because of a concussion suffered during the season opener against Jacksonville.
Houston running back Arian Foster is set to make his debut this season. He missed the first three games of the season after tearing his groin early in training camp.
Bears quarterback Jay Cutler makes his first start since he strained a hamstring in the first half of a 48-23 loss to Arizona on Sept. 20. He will be without one of his favorite targets in wide receiver Alshon Jeffery, who is out for the third straight week with a hamstring injury.
JACKSONSVILLE AT INDIANAPOLIS
Colts: QB Andrew Luck, CB Greg Toler, RB Tyler Varga, DT T.Y. McGill, OT Denzelle Good, G Todd Herremans, TE Dwayne Allen.
Jaguars: WR Marqise Lee, RB Denard Robinson, S Sergio Brown, G Brandon Linder, TE Julius Thomas, DE Chris Smith, DT Sen'Derrick Marks.
OAKLAND AT CHICAGO
Raiders: RB Taiwan Jones, CB Keith McGill, C Rodney Hudson, G Jon Feliciano, DT Matt McCants, DE Benson Mayowa, DL C.J. Wilson
Bears: QB David Fales, P Patrick O'Donnell, WR Alshon Jeffery, RB Ka'Deem Carey, C Hroniss Grasu, OT Jermon Bushrod, NT Jeremiah Ratliff.
NEW YORK GIANTS AT BUFFALO
Giants: WR Victor Cruz, DE Robert Ayers, TE Daniel Fells, S Cooper Taylor, LB Jasper Brinkley, DT Markus Kuhn, TE Jerome Cunningham.
Bills: WR LeSean McCoy, WR Sammy Watkins, S Aaron Williams, G John Miller, WR Marquise Goodwin, LB Tony Steward, DE Alex Carrington.
PHILADELPHIA AT WASHINGTON
Eagles: QB Thad Lewis, S Chris Maragos, LB Kiko Alonso, OL Julian Vandervelde, DE Cedric Thornton, LB Marcus Smith, and DE Taylor Hart
Redskins: QB Robert Griffin III, WR DeSean Jackson, WR Andre Roberts, CB DeAngelo Hall, LB Perry Riley Jr., DE Kedric Golston, and OT Tom Compton.
HOUSTON AT ATLANTA
Falcons: S Ricardo Allen, RB Tevin Coleman, C Gino Gradkowski, WR Justin Hardy, WR Devin Hester, T Jake Long, TE Jacob Tamme
Texans: S Lonnie Ballentine, OLB Kourtnei Brown, ILB Akeem Dent, RB Jonathan Grimes, C Greg Mancz, WR Jaelen Strong, WR Chandler Worthy
CAROLINA AT TAMPA BAY
Panthers: S Dean Marlowe, RB Brandon Wegher, LB Luke Kuechly, T Daryl Williams, G Amini Silatolu, WR Kevin Norwood, WR Jerricho Cotchery.
Buccaneers: QB Ryan Griffin, CB Johnthan Banks, S Major Wright, C Evan Smith, TE Austin Seferian-Jenkins, TE Luke Stocker, WR Russell Shepard.
KANSAS CITY AT CINCINNATI
Chiefs: QB Aaron Murray, WR Albert Wilson, CB Steven Nelson, LB Dezman Moses, OL Jah Reid, TE Brian Parker, DL Rakeem Nunez-Roches.
Bengals: WR Greg Little, WR Mario Alford, S George Iloka, TE C.J. Uzomah, DT Marcus Hardison, DT Brandon Thompson, DE Margus Hunt.
AP NFL website: www.pro32.ap.org and www.twitter.com/AP_NFL