Colts...28 Jaguars...25

INDIANAPOLIS -- The Indianapolis Colts are on the verge of their fifth straight AFC South title. They can thank Peyton Manning and instant replay.

Manning threw four touchdown passes, two after the Colts won replay challenges, and Indianapolis beat Jacksonville, 28-25, to take a two-game lead with four games to go.

It was the second victory by the Colts (10-2) over the Jaguars (8-4) this season, essentially giving them a three-game lead with four games left in a division they have controlled since Tennessee won it in the first year of its current configuration.

The Colts’ first two touchdowns came in a bizarre first quarter in which there were three replay challenges -- two won by Indianapolis, the other lost by Jacksonville.

Manning was 19 for 28 for 288 yards. He has 23 touchdown passes for the season, tying him with Dan Marino as the only quarterbacks to throw more than 20 in each of their first 10 NFL seasons.

Quoteworthy: “In all likelihood, they’ll win the division.” -- Jack Del Rio, Jaguars coach, on the Colts