Deschanel's rep confirmed the news to E! News on Friday.
The couple got married in September 2010 and welcomed son Henry about a year later. Hornsby, 39, has been on FX's
The elder Deschanel -- at 38, she's big sis to
Deschanel, David Boreanaz and the rest of the "Bones" cast can be seen next week in the Fox series' 200th episode, which airs Thursday.