Forty-nine people are dead and at least 53 injured in the deadliest shooting in American history after Omar Mateen, a 29-year-old U.S. citizen, opened fire and took hostages inside the Pulse gay nightclub in Orlando, Fla.

What we know:

Democrat mounts gun-control filibuster on U.S. Senate floor

Sen. Christopher S. Murphy, a Democrat from Connecticut who made gun control one of his priorities following the massacre of children at Sandy Hook Elementary in Newtown, Conn., in 2012, has taken control of the Senate floor .

He wants the Senate to vote on a measure banning anyone on the no-fly list from purchasing weapons, and says he won't yield his time until the vote happens. Murphy's Democratic colleagues, including Sen. Bill Nelson of Florida, have been joining him on the floor in support of the effort.

Nelson has been talking about the Orlando shooting rampage and pointedly noted that the assault weapon used Sunday morning to kill 49 people would have been banned had Congress not allowed the Assault Weapons Ban to expire in 2004.

As we have been reporting, Democrats in Congress have been pushing the issue in the U.S. House as well. The debate has led to high emotions and some lawmakers have been visibly angry as they attempt to force a vote.

C-Span has a livestream you can watch above, and some excerpts of Murphy's remarks are below.

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