During the regular season, the Spurs matched New Orleans for the best record in the Southwest Division at 56-26.
But against the point spread, San Antonio finished under .500 at 38-44.
In the playoffs, it's a similar story for the Spurs, who defeated Phoenix, 4-1, in the first round. Despite dominating the Suns for chunks at a time, San Antonio was only 2-2-1 against the point spread.
That sets the stage for the Spurs' second-round matchup against the Hornets, who split four games (2-2) with San Antonio this season.
Behind the stellar play of guard Chris Paul, New Orleans made it look easy in defeating Dallas, 4-1, in the first round. But the Hornets were only 3-2 against the point spread.
So despite having home-court advantage over San Antonio in the series, New Orleans is listed as the underdog at +120, according to Sportsbook.com.
The Spurs are listed as the favorite at -150.
Yet for tonight's Game 1, Las Vegas oddsmakers have pegged the Hornets as a three-point home favorite.
New Orleans has several positive betting trends working in its favor heading into the series.
The Hornets are 5-0 against the point spread in their last five games as a home favorite between 0.5 and 4.5 points and they are 6-0 against the point spread in their last six home games versus a team with a winning road record.
Unlike New Orleans, San Antonio has a few negative betting trends to overcome.
The Spurs are 1-5 against the point spread in their last six road games, 4-9 against the point spread in their last 13 games as an underdog, and 5-13 against the point spread in their last 18 games as a road underdog.
After defeating the Flyers in overtime to start the series, the Canadiens have lost three games in a row to the Flyers heading into tonight's Game 5 at the Bell Centre.
But despite their recent slide, the Canadiens are favored to win tonight on the money line at -165, according to Sportsbetting.com. The Flyers are listed at +145.
At wagerline.com, Montreal has received 63.3% of the picks for tonight's game.