Notre Dame 35, Burroughs 14--Todd Fenton caught two touchdown passes in the second half to help spark the Knights (2-0) at Burroughs (0-2).
Fenton finished with three catches for 110 yards and put the game away with an 81-yard touchdown reception from quarterback Seth Oseransky with 7:17 left to play.
Oseransky, who alternated at quarterback with Jonathon Brewster, completed four of six for 137 yards and three touchdowns.
Burroughs took a 14-0 lead in the first quarter on a six-yard touchdown run and a 70-yard interception return by Mike Holmes.
But the Indians committed four turnovers and a roughing the kicker penalty, which led to Notre Dame's first score.