Louisville Stunned, 45-14

Receiver Amarri Jackson ran for two touchdowns and threw for a third Saturday night to lead South Florida to the biggest victory in the school’s brief football history, a 45-14 rout of No. 9 Louisville in a Big East Conference game at Tampa, Fla.

After barely playing a role in the offense in his team’s first three games, Jackson showed his versatility in helping South Florida (3-1, 1-0) beat a ranked opponent for the first time in six tries and stop the nation’s third-longest Division I-A winning streak at nine games. It was South Florida’s Big East debut.

Louisville (2-1, 0-1) had not lost since a 41-38 setback at Miami last Oct. 14.

South Florida, which is in its ninth season, also upset Louisville two years ago in the Bulls’ Conference USA debut. The Bulls and Cardinals left for the higher profile Big East after last season.

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In other games involving Big East teams: Tyler Palko shrugged off two early turnovers to throw for three touchdowns and Raymond Kirkley scored in the first two minutes of each half to lead Pittsburgh (1-3) to a 41-0 victory over visiting Youngstown State (3-1) -- the Panthers’ first win under Coach Dave Wannstedt.... Adam Bednarik and Pat White each threw a touchdown pass and Antonio Lewis returned a punt 76 yards for a score to carry West Virginia (4-0) to a 20-15 win over East Carolina (1-2) at Morgantown, W.Va.

EAST

Nate Meyer kicked a 33-yard field goal as time expired to give Western Michigan (2-2) a 19-16 win over Temple (0-4) at Philadelphia.

MIDWEST

Andrew Wellock kicked three field goals, including the game winner, to lead Eastern Michigan (2-2, 1-0) to a 23-20 overtime win over Central Michigan (1-3, 1-1) in a Mid-American Conference game at Mount Pleasant, Mich.... Kalvin McRae rushed for 200 yards and two touchdowns and Voncarie Owens ran for 139 yards and two scores to lead Ohio (2-2, 1-0) to a 35-32 win over Kent State (1-3, 0-1) in a MAC game at Athens, Ohio.... Brett Biggs scored on a one-yard touchdown run in overtime and Akron (2-1, 1-0) avoided blowing a 21-point fourth-quarter lead with a 48-42 win over Northern Illinois (1-3, 0-1) in a MAC game at Akron, Ohio.

SOUTH

Central Florida (1-2, 1-0) ended major college football’s longest losing streak at 17 games with a 23-13 victory over Marshall (1-2, 0-1) in a Conference USA game at Orlando, Fla. It was the first win for second-year Coach George O’Leary.... Joe Smith caught two touchdown passes and the defense had five interceptions to lead Arkansas State (2-2, 1-0) to a 66-24 victory over Florida International (0-3, 0-1) in a Sun Belt Conference game at Jonesboro, Ark.

SOUTHWEST

Lester Ricard passed for 213 yards and two touchdowns to lead Tulane (1-1, 1-0) to a 31-10 victory over Southern Methodist (1-3, 0-1) in a Conference USA game at Dallas.... Paul Smith threw a 25-yard touchdown pass to Garrett Mills on the first play of overtime to lead Tulsa (2-2, 1-0) to a 37-31 win over Memphis (1-2, 0-1) in a Conference USA game at Tulsa, Okla.... Joe Fleskoski returned an interception 68 yards for a touchdown and Nate Draughon recovered a blocked punt in the end zone to lead Texas El Paso (3-0) to a 21-13 win over visiting New Mexico (3-1).

ROCKIES

Kyle Bell rushed for a career-high 183 yards to lead Colorado State (1-2) to a 42-21 victory over Nevada (1-2) at Fort Collins, Colo.... Leon Jackson III threw for 212 yards and two touchdowns, the final one a 15-yarder in the fourth quarter, to lead Utah State (1-1) to a 31-24 victory over Nevada Las Vegas (1-3) at Logan, Utah.

WEST

Kevin O’Connell passed for career bests in yardage (271) and touchdowns (four) to lead San Diego State (1-3) to a 52-21 win over visiting San Jose State (1-2).... Colt Brennan threw three touchdown passes to lead Hawaii (1-2, 1-0) to a 24-0 victory over Idaho (0-4, 0-1) in a Western Athletic Conference game at Moscow, Idaho.

SOUTHLAND

Andy Collins threw for 247 yards and four touchdowns to lead host Occidental (3-0, 1-0) to a 41-9 win over Cal Lutheran (1-1, 0-1) in a SCIAC game.... Robert Pepple rushed for 158 yards and scored a touchdown to lead Pomona-Pitzer (2-2, 1-1) to a 24-9 win over host Whittier (2-1, 0-1) in a SCIAC game.... Quarteback Brian Guerrero passed for 384 yards and four touchdowns to lead La Verne (2-1) to a 38-14 victory over visiting Puget Sound (2-1).... Adam Brown returned a fumble 14 yards for a touchdown to lead Redlands (1-2) to a 31-14 win over host Chapman (0-3).... Marcus Lampkin rushed for 112 yards and Azusa Pacific (2-2) scored all its points in the first quarter in a 13-12 victory over Humboldt State (3-1) at Arcata, Calif.... Quarterback Anthony Garnett rushed for three touchdowns to lead Cal Poly San Luis Obispo (3-1, 1-0) to a 24-16 victory over South Dakota State (2-2, 0-1) at Brookings, S.D., in a Great West Conference game.... Jay McCareins returned his third interception of the game 99 yards to lead Princeton (2-0) to a 20-17 victory over San Diego (3-1) at Princeton, N.J., ending the Toreros’ eight-game winning streak.