The Panthers made six three-point shots during a decisive 31-6 run to upset the fifth-ranked Hoyas, 75-56, in a Big East game Wednesday night.
They also held Hoya scoring star Allen Iverson to 12 points.
Pittsburgh, 7-3 overall and 2-1 in the Big East, hadn't beaten a team as highly rated as Georgetown since a 99-91 victory over No. 3 Oklahoma during the 1988-89 season.
The Hoyas (13-2, 3-1) shot only 30.6% and made only two field goals during the first 12 minutes of the second half as their 10-game winning streak ended.
The game had been postponed one night because of the weekend blizzard that struck Washington.
No. 1 Massachusetts 94, St. Joseph's 89--Marcus Camby scored 34 points and Edgar Padilla added 20 to lead the Minutemen (13-0, 2-0) to an overtime Atlantic 10 Conference victory over the Hawks (4-5, 0-1) at Philadelphia.
St. Joseph's' Terrell Myers sent the game into overtime, making three free throws with less than a second to play to tie the game, 79-79. The Minutemen never trailed in the extra period.
No. 8 Wake Forest 57, Duke 54--Tim Duncan shook off a poor-shooting first half to score 24 points, including the go-ahead layup with 47 seconds to play as the Demon Deacons (9-1, 2-0) defeated the Blue Devils (9-5, 0-3) in an Atlantic Coast Conference game at Durham, N.C.
Georgia Tech 80, No. 10 North Carolina 77--Drew Barry made two free throws with 2.5 seconds to play after hustling to the baseline to rebound his own missed free throw four seconds earlier as the Yellow Jackets (9-7, 3-0) survived a late comeback to defeat the Tar Heels (11-3, 2-1) in an ACC game at Atlanta.
No. 11 Iowa 81, Ohio State 53--Jess Settles scored 20 points and Russ Millard added 14 as the Hawkeyes (13-2, 2-1) forced 30 turnovers to defeat the Buckeyes (7-5, 0-3) in a Big Ten game at Iowa City.
No. 13 Utah 69, Air Force 45--Brandon Jessie broke out of a shooting slump with a season-high 21 points as the Utes (10-3, 2-1) beat the Falcons (4-9, 0-4) in an Western Athletic Conference game at Salt Lake City.
No. 14 Syracuse 77, Providence 75--Syracuse made 16 consecutive free throws and Todd Burgan scored 13 of his 18 points in the second half as the Orangemen (12-2, 3-1) defeated the Friars (8-5, 1-4) in a Big East game at Syracuse.
No. 15 Virginia Tech 88, Duquesne 69--Ace Custis had 18 points, 17 rebounds and six assists as the Hokies (8-1, 1-0) defeated Duquesne (5-6, 0-2) in their Atlantic 10 Conference debut at Pittsburgh.
The Hokies joined the Atlantic 10 from the defunct Metro Conference.
No. 18 Arizona 108, Arizona State 76--Reserve Joe McLean scored 22 points in a 10-minute span of the first half to break open a close game and the Wildcats (11-3, 1-2) defeated the Sun Devils (5-6, 0-3) in a Pacific 10 Conference game at Tucson. McLean had a career-high 30 points.
No. 22 Purdue 67, Northwestern 51--Brad Miller scored 15 points and the Boilermakers (12-2, 2-0) started the second half with a 20-5 run to defeat the Tigers (5-6, 0-2) in a Big Ten game at Evanston, Ill.
No. 25 New Mexico 78, Hawaii 72--Freshman Kenny Thomas posted career-highs of 26 points and six blocks and the Lobos (13-1, 3-1) held on to defeat the Rainbows (4-8, 1-3) in a Western Athletic Conference game at Albuquerque.
Jeff Campbell scored 22 points to rally Brigham Young (8-4, 2-1) to a 97-84 victory over Fresno State (9-5, 3-1) in a WAC game at Provo, Utah. The victory ended Fresno State's six-game winning streak. . . . Roy Hammonds scored 13 points, all in the second half, and San Jose State (4-8, 3-1) held on to to post a 66-64 Big West Conference victory over Nevada Las Vegas (4-7, 1-2) at San Jose. . . . Levell Sanders put Seton Hall ahead with two free throws with 24 seconds to play and the Pirates (7-5, 3-2) posted a 66-63 victory over Miami (8-5, 2-3) in a Big East game at East Rutherford, N.J.